Soluble CD109 binds TGF-β and antagonizes TGF-β signalling and responses
Abstract
Transforming growth factor-β (TGF-β) is a multifunctional cytokine implicated in many diseases, including tissue fibrosis and cancer. TGF-β mediates diverse biological responses by signalling through type I and II TGF-β receptors (TβRI and TβRII). We have previously identified CD109, a glycosylphosphatidylinositol (GPI)-anchored protein, as a novel TGF-β co-receptor that negatively regulates TGF-β signalling and responses and demonstrated that...
Paper Details
Title
Soluble CD109 binds TGF-β and antagonizes TGF-β signalling and responses
Published Date
Feb 24, 2016
Journal
Volume
473
Issue
5
Pages
537 - 537
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