CB2 cannabinoid receptor stimulation attenuates TNF‐alpha‐induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte‐endothelial adhesion.

Targeting cannabinoid‐2 (CB2) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms by which CB2 activation exerts its anti‐inflammatory effects and the cellular targets are elusive. Here, we investigated the effects of CB2‐receptor activation on TNF‐alpha‐induced signal transduction in human coronary artery endothelial cells in vitro and on endotoxin‐induced vascular...