Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma

Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal carcinomas, but their biology is incompletely understood. We performed a clinicopathological and molecular analysis of a large number of the rarely observed SSAs with dysplasia/carcinoma to better define their features and the pathways by which they progress to carcinoma.A cross-sectional analysis of 137 SSAs containing regions of dysplasia/carcinoma prospectively...