Sacubitril/Valsartan
Abstract
Sacubitril/valsartan [LCZ696 (Entresto), Novartis Pharmaceuticals Corp.] is the first in a new class of drugs that combines neprilysin inhibition with angiotensin II receptor antagonism, the combination of which acts to increase endogenous natriuretic peptides while inhibiting the renin–angiotensin–aldosterone system. Sacubitril/valsartan has been studied in the treatment of hypertension, heart failure with reduced ejection fraction (HFrEF), and...
Paper Details
Title
Sacubitril/Valsartan
Published Date
Jan 1, 2016
Journal
Volume
24
Issue
1
Pages
41 - 47
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Notes
History