Immunochemical detection of sulfur mustard-adducts with DNA and proteins: Exploratory research on adducts with proteins

We have developed two modes of a standard operating procedure (SOP) for immunochemical detection of sulfur mustard adducts to DNA in human blood and skin. In the shortened mode data could be generated within 9 h after in vitro exposure of human blood to > 1 μM sulfur mustard. The sensitive mode allows detection of exposure to 50 nM sulfur mustard. The in vivo adduct level in blood in hairless guinea pigs remained constant during the first two...