Synthetic inhibitors of matrix metalloproteinases prevent sulfur mustard-induced epidermal-dermal separation in human skin pieces
Pages: 588
Published: Jan 1, 2000
Abstract
Degradation of proteins of the basement membrane zone (BMZ) in the skin depends on the activity of proteolytic enzymes, particularly those belonging to the group of matrix metalloproteinases (MMPs). In the present study we have investigated the contribution of these enzymes to the epidermal-dermal separation in human skin pieces that had been exposed to saturated vapor of HD at 25 oC. The release of MMP-1, MMP-2, MMP-3 and MMP-9 in the organ...
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