Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion

ObjectiveChondrocyte dedifferentiation is known to influence cell mechanics leading to alterations in cell function. This study examined the influence of chondrocyte dedifferentiation in monolayer on cell viscoelastic properties and associated changes in actin organisation, bleb formation and membrane-actin cortex interaction.MethodMicropipette aspiration was used to estimate the viscoelastic properties of freshly isolated articular chondrocytes...