Feline Central Retinal Degeneration

Published on Aug 1, 1974in Investigative Ophthalmology & Visual Science3.47
Roy W. Bellhorn13
Estimated H-index: 13
(Albert Einstein College of Medicine),
Gustavo D. Aguirre67
Estimated H-index: 67
(UPenn: University of Pennsylvania),
Margaret B. Bellhorn8
Estimated H-index: 8
(Albert Einstein College of Medicine)
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#1Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
The aim of this review is to introduce the reader to the world of clinical veterinary electroretinography. An important indication for ERG recordings in the dog is the early diagnosis of progressive retinal atrophy, an inherited form of photoreceptor degeneration, analogous to retinitis pigmentosa in humans. In most of the 20 canine breeds in which the disease has been studied electrophysiologically, changes in the ERG appear long before the appearance of clinical signs. This early diagnosis is ...
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#1Humi Imaki (Ebor: University of York)H-Index: 7
#1Humi Imaki (York University)H-Index: 12
Last. John A. SturmanH-Index: 22
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It has now been established that cats are dependent on dietary sources of taurine to maintain their body reserve, and when deprived, they develop a variety of disorders including retinal degeneration, myocardial failure, depressed immune responsiveness and extensive reproductive deficits37,38,39. Feline central retinal degeneration, a photoreceptor degenerative condition originally described as bilaterally symmetrical generalized focal lesions of unknown etiology3,4,26, was among the first to be...
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#1Arnold Leon (ANU: Australian National University)H-Index: 1
#2W. R. Levick (ANU: Australian National University)H-Index: 9
Last. Marc Sarossy (ANU: Australian National University)H-Index: 10
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Previous studies of feline taurine deficiency retinopathy have established that the retinopathy begins as a focal lesion at the area centralis (feline central retinal degeneration) and progresses to form a horizontal band of retinal degeneration which, in some cases, eventually involves the whole retina. Several theories have been proposed to account for the strikingly unusual geographic distribution of lesions in this disease. including a preferential cone photoreceptor effect, and damage by ex...
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#1W. R. Levick (ANU: Australian National University)H-Index: 9
#2L.N. Thibos (IU: Indiana University Bloomington)H-Index: 1
Receptive fields of ganglion cells have been studied in cats possessing a chronic, arrested lesion of central retinal degeneration. Lesions were characterized by an ophthalmoscopically sharp border separating apparently normal retina from the region of the lesion. Under direct ophthalmoscopic guidance, a succession of recordings was obtained from ganglion cells having cell bodies at various positions relative to the lesion. Cells located more than 1 deg outside the ophthalmoscopic border had nor...
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#1Brian P. Wilcock (Ontario Veterinary College)H-Index: 2
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#1P. D. PionH-Index: 1
#2M. D. Kittlesont (UC Davis: University of California, Davis)H-Index: 1
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#1Nicholas J. Millichamp (A&M: Texas A&M University)H-Index: 4
#1Nicholas J. Millichamp (The American College of Financial Services)H-Index: 1
Retinal degeneration is a common cause of blindness in dogs and cats. Inherited progressive retinal atrophy is seen frequently in dogs in clinical practice. Recent studies of progressive retinal atrophy have permitted the development of a classification scheme for these diseases. Noninherited retinal degeneration may result from several causes in both the dog and cat.
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#1Erik Vandenbussche (UCL: Université catholique de Louvain)H-Index: 26
#2Ulf T. Eysel (RUB: Ruhr University Bochum)H-Index: 68
Last. Guy Orban (UCL: Université catholique de Louvain)H-Index: 103
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Abstract Grating acuity was investigated behaviorally in the cat. Retinal lesions of increasing diameter centered on the area centralis were made by photocoagulations in one eye, while the intact eye was used as control. Lesion size evaluated from fundus photographs was precisely correlated with the anatomical lesion size measured in retinal whole mounts. Grating acuity improved with increasing grating area in cats with intact retinae and after small ( 4° diameter). Overall, grating acuity clear...
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#1P. G. C. Bedford (RVC: Royal Veterinary College)H-Index: 12
The term progressive retinal atrophy (PRA) is synonymous with inherited blindness in both dogs and cats as the result of retinal degeneration. In fact several types of degeneration occur within this complex, but the ophthalmoscopic features are well recognised and practical disease control is possible through routine examination. However, effective measures demand the whole-hearted support of the breeds involved, and only extensively applied examination schemes in which there is a central poolin...
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