Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro : Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis

Volume: 105, Issue: 2, Pages: 808 - 816
Published: Feb 1, 2016
Abstract
Our previous study demonstrated that daphnetin is subject to glucuronidation in vitro. However, daphnetin metabolism is still poorly documented. This study aimed to investigate daphnetin metabolism and its consequent effect on the bioactivity. Metabolic profiles obtained by human liver S9 fractions and human hepatocytes showed that daphnetin was metabolized by glucuronidation, sulfonation, and methylation to form 6 conjugates which were...
Paper Details
Title
Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro : Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis
Published Date
Feb 1, 2016
Volume
105
Issue
2
Pages
808 - 816
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