Genotype Imputation with Millions of Reference Samples
Abstract
We present a genotype imputation method that scales to millions of reference samples. The imputation method, based on the Li and Stephens model and implemented in Beagle v.4.1, is parallelized and memory efficient, making it well suited to multi-core computer processors. It achieves fast, accurate, and memory-efficient genotype imputation by restricting the probability model to markers that are genotyped in the target samples and by performing...
Paper Details
Title
Genotype Imputation with Millions of Reference Samples
Published Date
Jan 1, 2016
Volume
98
Issue
1
Pages
116 - 126
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