Competition between DNA methylation and transcription factors determines binding of NRF1

Nature64.80
Volume: 528, Issue: 7583, Pages: 575 - 579
Published: Dec 24, 2015
Abstract
Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only a fraction of their corresponding DNA sequence motifs in any given cell type. Chromatin has the potential to restrict accessibility of binding sites; however, in which context chromatin states are instructive for TF binding remains mainly unknown. To explore the contribution of DNA methylation to constrained TF binding, we mapped...
Paper Details
Title
Competition between DNA methylation and transcription factors determines binding of NRF1
Published Date
Dec 24, 2015
Journal
Volume
528
Issue
7583
Pages
575 - 579
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