Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing
Abstract
Site-specific chemical dimerization of fibroblast growth factor 2 (FGF2) with the optimal linker length resulted in a FGF2 homodimer with improved granulation tissue formation and blood vessel formation at exceptionally low concentrations. Homodimers of FGF2 were synthesized through site-specific linkages to both ends of different molecular weight poly(ethylene glycols) (PEGs). The optimal linker length was determined by screening dimer-induced...
Paper Details
Title
Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing
Published Date
Mar 1, 2016
Journal
Volume
81
Pages
157 - 168
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