Validation of an Animal Isolation Imaging Chamber for use in Animal Biosafety Level-3 Containment

Live imaging of animals infected with pathogenic microbes poses a contamination risk to equipment, personnel, and other animals. A Caliper animal isolation chamber designed for the IVIS® Spectrum imaging system was tested as a containment device for mice infected with microbes assigned to animal biosafety level-3 (ABSL-3). A testing protocol was developed by adapting two published standards to test other equipment in high-containment...