The many faces of Mac‐1 in autoimmune disease

Summary Mac‐1 (CD11b/CD18) is a β2 integrin classically regarded as a pro‐inflammatory molecule because of its ability to promote phagocyte cytotoxic functions and enhance the function of several effector molecules such as FcγR, uPAR, and CD14. Nevertheless, recent reports have revealed that Mac‐1 also plays significant immunoregulatory roles, and genetic variants in ITGAM , the gene that encodes CD11b, confer risk for the autoimmune disease...