Chronic granulomatous disease: Clinical, molecular, and therapeutic aspects

Chronic granulomatous disease ( CGD ) is a rare primary immunodeficiency caused by defects in the genes encoding any of the NADPH oxidase components responsible for the respiratory burst of phagocytic leukocytes. CGD is a genetically heterogeneous disease with an X‐linked recessive ( XR ‐ CGD ) form caused by mutations in the CYBB gene encoding the gp91 phox protein, and an autosomal recessive ( AR ‐ CGD ) form caused by mutations in the CYBA ,...