Highly efficient nuclear delivery of anti-cancer drugs using a bio-functionalized reduced graphene oxide
Abstract
Targeted drug delivery has become important, attractive and challenging in biomedical science and applications. Anti-HER2 antibody-conjugated poly-l-lysine functionalized reduced graphene oxide (anti-HER2-rGO-PLL) nanocarriers were prepared to efficiently deliver doxorubicin targeting at the nucleus of HER2 over-expressing cancer cells. The polycationic PLL was first covalently grafted to graphene oxide (GO) nanosheets followed by reduction to...
Paper Details
Title
Highly efficient nuclear delivery of anti-cancer drugs using a bio-functionalized reduced graphene oxide
Published Date
Apr 1, 2016
Volume
467
Pages
35 - 42
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