Alcoholic Liver Disease: from CYP2E1 to CYP2A5
Abstract
This article reviews recent studies on CYP2E1-mediated alcoholic liver injury, the induction of CYP2A5 by alcohol and the mechanism for this upregulation, especially the permissive role of CYP2E1 in the induction of CYP2A5 by alcohol and the CYP2E1-ROS-Nrf2 pathway, and protective effects of CYP2A5 against ethanol-induced oxidative liver injury. Ethanol can induce CYP2E1, an active generator of reactive oxygen species (ROS), and CYP2E1 is a...
Paper Details
Title
Alcoholic Liver Disease: from CYP2E1 to CYP2A5
Published Date
May 10, 2017
Volume
10
Issue
3
Pages
172 - 178
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