Design, synthesis and biochemical evaluation of novel CK2 and CDK2 inhibitors

Kinases are a class of enzymes, which catalyse the transfer of the terminal phosphate of a molecule of ATP, or more rarely of GTP, to a protein that acts as a substrate. This process is reversible and is maintained by the presence of other enzymes, namely the phosphatases, which catalyse the reverse reaction. An imbalance between these enzymes plays a crucial role in the occurrence of diseases, which is attributable to abnormal levels of...