Trends in the psychopharmacological treatment of bipolar disorder: a nationwide register-based study

Objective In bipolar disorder, treatment with antidepressants without concomitant use of mood stabilisers (antidepressant monotherapy) is associated with development of mania and rapid cycling and is therefore not recommended. The present study aimed to investigate the psychopharmacological treatment patterns in bipolar disorder over time, with a focus on antidepressant monotherapy. Methods Cohort study with annual cross-sectional assessment of...