Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model
Abstract
In an established steroid-associated osteonecrosis (SAON) rabbit model we found recently that blockage Src by siRNA could improve reconstructive repair of osteonecrosis via enhancing osteogenesis and inhibiting bone resorption. The current study investigated if blocking Src was able to prevent steroid-associated osteoporosis (SAOP) in the same SAON animal model. Rabbits were treated with pulsed lipopolysaccharide (LPS) and corticosteroid...
Paper Details
Title
Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model
Published Date
Feb 1, 2016
Journal
Volume
83
Pages
190 - 196
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