Aflibercept Traps Galectin-1, an Angiogenic Factor Associated with Diabetic Retinopathy
Abstract
Vascular endothelial growth factor (VEGF)-A-driven angiogenesis contributes to various disorders including cancer and proliferative diabetic retinopathy (PDR). Among several VEGF-A blockers clinically used is aflibercept, a chimeric VEGFR1/VEGFR2-based decoy receptor fused to the Fc fragment of IgG1 (i.e., VEGFR1/VEGFR2-Fc). Here, we revealed a novel anti-angiogenic function for aflibercept beyond its antagonism against VEGF family members....
Paper Details
Title
Aflibercept Traps Galectin-1, an Angiogenic Factor Associated with Diabetic Retinopathy
Published Date
Dec 9, 2015
Journal
Volume
5
Issue
1
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