The moderation of elastase-induced emphysema in the hamster by intratracheal pretreatment or post-treatment with succinyl alanyl alanyl prolyl valine chloromethyl ketone.

Published on Jul 1, 1981in The American review of respiratory disease
· DOI :10.1164/ARRD.1981.124.1.56
Phillip J. Stone40
Estimated H-index: 40
Edgar C. Lucey26
Estimated H-index: 26
+ 4 AuthorsJames C. Powers63
Estimated H-index: 63
The capacity of the synthetic elastase inhibitor, succinyl alanyl alanyl prolyl valine chloromethyl ketone (CMK), to moderate elastase-induced emphysema in hamsters was examined using morphometric and physiologic measurements. When 0.5 mg of CMK in saline was injected intratracheally 1 h before the intratracheal injection of 0.1 mg of porcine pancreatic elastase, the hamsters did not develop emphysema. When CMK was injected intratracheally 1 h after elastase, the severity of emphysema was reduced by approximately 50% compared with control animals receiving saline 1 h after elastase. The CMK was ineffective when administered tntratracheally 4 h after elastase.
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