New natural product carbonic anhydrase inhibitors incorporating phenol moieties
Abstract
Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the fundamental reaction of CO2 hydration in all living organisms, being actively involved in the regulation of a plethora of patho/physiological conditions. They represent a typical example of enzyme convergent evolution, as six genetically unrelated families of such enzymes were described so far. The need to find selective CA inhibitors (CAIs) triggered the investigation of natural product...
Paper Details
Title
New natural product carbonic anhydrase inhibitors incorporating phenol moieties
Published Date
Nov 1, 2015
Volume
23
Issue
22
Pages
7219 - 7225
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