Adipose-Derived Stem Cells: Origin and Lineage

Published on Jan 1, 2011
KG Marra2
Estimated H-index: 2
,
Kacey G. Marra64
Estimated H-index: 64
+ 0 AuthorsJ. Peter Rubin61
Estimated H-index: 61
(University of Pittsburgh)
Abstract
Background: The potential of using mesenchymal stem cells derived from adipose tissue to enhance wound healing is significant. Considerable advances in both basic science and clinical research are being attained. The Problem: Nonhealing wounds remain a significant challenge for plastic surgeons. More than 600,000 people suffer from venous ulcers and 1.5‐3 million people are being treated for pressure sores every year in the United States. Basic/Clinical Science Advances: The use of tissue engineering techniques such as stem cell therapy and gene therapy to improve wound healing is a promising strategy. Adipose tissue represents a source of cells that may be able to enhance wound healing. Adipose-derived stem cells (ASCs) are adult mesenchymal stem cells that are easily harvested and of great interest in regenerative medicine applications. Specifically, ASCs secrete angiogenic growth factors and cytokines that can induce and enhance wound healing. Clinical Care Relevance: The improvement of angiogenesis, and hence vascularization, to the wound site will have a profound impact on the regeneration of tissue in impaired wound healing sites. Conclusions: This chapter describes innovative research strategies using ASC therapies for treatment of chronic, nonhealing wounds. These therapies include direct application of ASCs to wounds as well as the combination of ASCs with biomaterials.
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