β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer
Abstract
Integrins belong to a large family of αβ heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells. As important sensors of the cell microenvironment, they regulate numerous signaling pathways in response to structural variations of the extracellular matrix. Biochemical and biomechanical cues provided by this matrix and transmitted...
Paper Details
Title
β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer
Published Date
Nov 24, 2015
Journal
Volume
6
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