Comparative hepatoprotective activity of Mikania scandens (l.) willd.(MS) against a well-established hepatoprotective drug Silymarin was assessed against Diclofenac sodium(DF) induced liver injury in albino rats. Animals were injected with Diclofenac sodium at the single dose of 150 mg/ kg body weight intraperitonially once daily for 28 days. Diclofenac was used as the toxicant in hepatoprotective studies, in which various serum biochemical parameters and hepatic oxidative stress parameters were assessed. The hepatoprotective effect of Mikania scandens (l.) willd. (500 mg/kg) and its ethyl acetate ,n-hexane fractions(500 mg/kg) were comparatively evaluated with Silymarin by measuring levels of serum biochemical parameters such as aspartate aminotrasferase(AST), alanine aminotrasferase(ALT), alkaline phosphatase (ALP), total bilirubin (TB), total protein (TP), triglycerides, cholesterol and the hepatic oxidative stress parameters like as levels of, malondialdehyde(MDA), reduced glutathione (GSH), catalase(CAT)...

Chemistry

Pharmacology

Traditional medicine

Oxidative stress

Glutathione

Malondialdehyde

Catalase

Alkaline phosphatase

Bilirubin

Diclofenac Sodium

HEPATOPROTECTIVE ACTIVITY OF MIKANIA SCANDENS (L.) WILLD. AGAINST DICLOFENAC SODIUM INDUCED LIVER TOXICITY IN RATS