Incidence of Adverse Drug Reactions in Hospitalized Patients

Published on Jan 1, 2015
Jason Lazarou5
Estimated H-index: 5
Bruce H. Pomeranz3
Estimated H-index: 3
Paul N. Corey3
Estimated H-index: 3
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3 Authors (Jason Lazarou, ..., Paul N. Corey)
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OBJECTIVES: This report presents 1998 national estimates and selected trend data on the use of non-Federal short-stay hospitals in the United States. Estimates are provided by demographic characteristics of patients discharged, geographic region of hospitals, conditions diagnosed, and surgical and nonsurgical procedures performed. Measurements of hospital use include number and rate of discharges and days of care, and the average length of stay. Estimates of first-listed diagnoses, days of care,...
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OBJECTIVE: To describe the nature and frequency of adverse events (AEs) reported in routine inpatient data collection. DESIGN: Retrospective analysis of data from the Victorian Inpatient Minimum Database. SETTING: All public (135) and private (112) acute-care hospitals in Victoria, 1994-1995. PARTICIPANTS: All patients with separations recording an E-code identified as an AE through the International classification of diseases, ninth revision (ICD-9), classification system. MAIN OUTCOME MEASURES...
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#1David W. Bates (Harvard University)H-Index: 175
#2Nathan Spell (Harvard University)H-Index: 2
Last. Lucian L. Leape (Harvard University)H-Index: 84
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Objective. —To assess the additional resource utilization associated with an adverse drug event (ADE). Design. —Nested case-control study within a prospective cohort study. Participants. —The cohort included 4108 admissions to a stratified random sample of 11 medical and surgical units in 2 tertiary-care hospitals over a 6-month period. Cases were patients with an ADE, and the control for each case was the patient on the same unit as the case with the most similar pre-event length of stay. Main ...
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#1David C. Classen (LDS Hospital)H-Index: 61
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Objective. —To determine the excess length of stay, extra costs, and mortality attributable to adverse drug events (ADEs) in hospitalized patients. Design. —Matched case-control study. Setting. —The LDS Hospital, a tertiary care health care institution. Patients. —All patients admitted to LDS Hospital from January 1, 1990, to December 31,1993, were eligible. Cases were defined as patients with ADEs that occurred during hospitalization; controls were selected according to matching variables in a ...
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#1Kent M. Nelson (University of Texas at Austin)H-Index: 1
#2Robert L. Talbert (University of Texas at Austin)H-Index: 26
To describe the frequency and pattern of drug-related morbidity that results in hospital admission and the extent to which these admissions are avoidable, we prospectively reviewed the charts of 452 consecutive patients admitted to the intensive care unit or internal medicine service of a university-affiliated, county hospital. Of these, 73 (16.2%) were admitted due to drug-related morbidity. Forty patients (54.8%) experienced drug therapy failure, 24 (32.9%) had an adverse reaction, and 9 (12.3...
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#1Graham A. Colditz (Harvard University)H-Index: 296
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#1David W. Bates (Brigham and Women's Hospital)H-Index: 175
#3Nan M. Laird (Harvard University)H-Index: 118
Last. Hallisey RH-Index: 2
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Objectives. —To assess incidence and preventability of adverse drug events (ADEs) and potential ADEs. To analyze preventable events to develop prevention strategies. Design. —Prospective cohort study. Participants. —All 4031 adult admissions to a stratified random sample of 11 medical and surgical units in two tertiary care hospitals over a 6-month period. Units included two medical and three surgical intensive care units and four medical and two surgical general care units. Main Outcome Measure...
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#1David W. Bates (Brigham and Women's Hospital)H-Index: 175
#2Deborah BoyleH-Index: 6
Last. Lucian L. LeapeH-Index: 84
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OBJECTIVE: To evaluate the frequency of medication errors using a multidisciplinary approach, to classify these errors by type, and to determine how often medication errors are associated with adverse drug events (ADEs) and potential ADEs.
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Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics. The redox status regulates the level of reactive oxygen and nitrogen species (RONS). RONS interplay and modulate the action of diverse biomolecules, such as inflammatory mediators and drugs. In this review, we address the role of the redox status in the initia...
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PURPOSE Rib fractures, though typically associated with blunt trauma, can also result from complications of medical or surgical care, including cardiopulmonary resuscitation. The purpose of this study is to describe the demographics and outcomes of iatrogenic rib fractures. METHODS Patients with rib fractures were identified in the 2016 National Inpatient Sample. Mechanism of injury was defined as blunt traumatic rib fracture (BTRF) or iatrogenic rib fracture (IRF). IRF was identified as fractur...
#1Noe Garin (Autonomous University of Barcelona)H-Index: 15
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Last. Nuria Fonts (Autonomous University of Barcelona)H-Index: 1
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Drug-related problems (DRP) cause preventable negative health outcomes, especially during hospital admissions. The aim of our study was to examine the prevalence and characteristics of DRP in regular clinical pharmacy, as well as to determine those factors associated with a higher risk of DRP in the hospital setting. We analyzed data from a standardized registry database of regular pharmacy practice (2015- 2016). DRP were classified according to the Pharmaceutical Care Network Europe v6.2 classi...
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#1Donald W. Light (Rowan University)H-Index: 37
#2Joel Lexchin (York University)H-Index: 45
Abstract Drawing on economic theory and institutional analysis, this paper reframes Akerlof’s theory of how a market for lemons operates and argues that each of the many markets for lemons must be studied empirically to document how different stakeholders cope with the problems of information asymmetry, secrecy, and power. Such markets are a new field for sociological analysis. To illustrate, the paper characterizes pharmaceuticals as a multi-tier market of information asymmetry in which actors ...
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#1Emanuele MicaglioH-Index: 6
#2Emanuela T. LocatiH-Index: 3
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Adverse drug reactions (ADRs) are an important and frequent cause of morbidity and mortality. ADR can be related to a variety of drugs, including anticonvulsants, anaesthetics, antibiotics, antiretroviral, anticancer, and antiarrhythmics, and can involve every organ or apparatus. The causes of ADRs are still poorly understood due to their clinical heterogeneity and complexity. In this scenario, genetic predisposition towards ADRs is an emerging issue, not only in anticancer chemotherapy, but als...
#1Rodrigo Ramirez-Mendez (Catholic University of the Maule)
#2Xaviera A. López-Cortés (Catholic University of the Maule)H-Index: 5
Adverse drug reactions (ADRs) are defined as an unintended and harmful response that occurs with the ingestion of a certain drug. ADRs result in an appreciably harmful or unpleasant reaction that determines the success or failure of a drug. In this way, the generation of effective models for the prediction of ADR during the drug development process is of high relevance for human health. In this work, we present a complete proposal based on supervised machine learning to study dry mouth oral ADRs...
Purpose: This study was carried out to assess the rate and pattern of ADRs reporting in hospitalized patients at a teaching hospital. Method: A retrospective cross-sectional study was conducted in Balcali Hospital at Adana, Turkey during one year. The reports were examined on the basis of demographics, ADRs type, causality, severity, seriousness, drug characteristics and outcomes. WHO-UMC/ Naranjo algorithm scale, Hartwig and Siegel severity scale and pharmacovigilance contact point (PVCP) crite...
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#1Yitian Zhou (KI: Karolinska Institutet)H-Index: 10
#2Volker M. Lauschke (KI: Karolinska Institutet)H-Index: 30
Abstract In recent decades the identification of pharmacogenomic gene-drug associations has evolved tremendously. Despite this progress, a major fraction of the heritable inter-individual variability remains elusive. Higher-dimensional phenomena, such as gene-gene-drug interactions, in which variability in multiple genes synergizes to precipitate an observable phenotype have been suggested to account at least for part of this missing heritability. However, the identification of such intricate re...