COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma.
Abstract
Cyclooxygenase (COX) is an enzyme that converts arachidonic acid to prostanoids. There are two isoforms of COX, namely COX-1 and COX-2. COX-2 is highly inducible by several stimuli and is associated with inflammation. Recent studies have shown that COX-2 is upregulated in the airway epithelium of patients with asthma but little is known about the role it plays in cough, a common symptom of bronchial asthma. This study was designed to investigate...
Paper Details
Title
COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma.
Published Date
Jan 1, 2009
Journal
Volume
19
Issue
5
Pages
370 - 4
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Notes
History