Role of the orphan nuclear receptor RORγt in immune system homeostasis
Published: Jan 1, 2007
Abstract
T helper cells differentiate into lineages with distinct effector functions in response to the diverse cytokines induced following infection or tissue damage. In addition to Th1 and Th2 cells, T helper cells that secrete IL-17, IL22, and other pro-inflammatory cytokines (Th17 cells) were recently described. Cells of this lineage have key roles in mouse models of autoimmunity, and they are induced by a combination of TGF-β and IL-6, while their...
Paper Details
Title
Role of the orphan nuclear receptor RORγt in immune system homeostasis
Published Date
Jan 1, 2007
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