Functional site plasticity in domain superfamilies

Volume: 1834, Issue: 5, Pages: 874 - 889
Published: May 1, 2013
Abstract
We present, to our knowledge, the first quantitative analysis of functional site diversity in homologous domain superfamilies. Different types of functional sites are considered separately. Our results show that most diverse superfamilies are very plastic in terms of the spatial location of their functional sites. This is especially true for protein–protein interfaces. In contrast, we confirm that catalytic sites typically occupy only a very...
Paper Details
Title
Functional site plasticity in domain superfamilies
Published Date
May 1, 2013
Volume
1834
Issue
5
Pages
874 - 889
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