A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA A Receptors and Synaptic Inhibition
Abstract
Exogenously expressed opsins are valuable tools for optogenetic control of neurons in circuits. A deeper understanding of neural function can be gained by bringing control to endogenous neurotransmitter receptors that mediate synaptic transmission. Here we introduce a comprehensive optogenetic toolkit for controlling GABAA receptor-mediated inhibition in the brain. We developed a series of photoswitch ligands and the complementary genetically...
Paper Details
Title
A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA A Receptors and Synaptic Inhibition
Published Date
Dec 1, 2015
Journal
Volume
88
Issue
5
Pages
879 - 891
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