Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response

Volume: 15, Issue: 12, Pages: 712 - 729
Published: Dec 1, 2015
Abstract
Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic transformation. Increased activity and aberrant localization of proteases within the tumour microenvironment have a potent role in driving cancer progression, proliferation, invasion and metastasis. Recent studies have also uncovered functions for cathepsins in the suppression of the response to therapeutic intervention in various malignancies. However,...
Paper Details
Title
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
Published Date
Dec 1, 2015
Volume
15
Issue
12
Pages
712 - 729
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.