Combined platelet and plasma derivatives enhance proliferation of stem/progenitor cells maintaining their differentiation potential

Platelet derivatives have been proposed as alternatives to animal sera given that for cell therapy applications, the use of fetal bovine/calf serum (FBS/FCS) is subjected to severe limitations for safety and ethical concerns. We developed a cell culture medium additive obtained by the combination of two blood-derived standardized components.A platelet lysate (PL) and a platelet-poor plasma (PPP) were produced in a lyophilized form. Each...