Acute optic neuritis in multiple sclerosis

Published on Jun 14, 2016in Canadian Medical Association Journal7.744
· DOI :10.1503/CMAJ.150811
Brian Garrett2
Estimated H-index: 2
(Dal: Dalhousie University),
Adam A. Dmytriw14
Estimated H-index: 14
+ 0 AuthorsCharles Maxner1
Estimated H-index: 1
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Abstract
A 37-year-old woman presented to the emergency department with a two-week history of blurred central vision in her left eye. She had 20/20 vision in her right eye but could count fingers only at 1.2 m using her left eye. Confrontation visual field testing identified a central defect in her left eye
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Multiple sclerosis is an autoimmune demyelinating disorder of the nervous system, in which almost all patients develop some degree of visual impairment during the disease. Optic neuritis is the most common and known visual affection and may be the initial clinical disease manifestation, but visual complaints can have a wide variety of presentations and some of them can lead to clinical confusion. Most symptoms are the result of acute injury and subsequent axonal loss in the afferent and efferent...
4 CitationsSource
#1Hedieh Hoorbakht (Bharati Vidyapeeth University)H-Index: 1
#2Farid BagherkashiH-Index: 1
The aim of this review is to summarize the latest information about optic neuritis, its differential diagnosis and management. Optic Neuritis (ON) is defined as inflammation of the optic nerve, which is mostly idiopathic. However it can be associated with variable causes (demyelinating lesions, autoimmune disorders, infectious and inflammatory conditions). Out of these, multiple sclerosis (MS) is the most common cause of demyelinating ON. ON occurs due to inflammatory processes which lead to act...
67 CitationsSource
#1Edward J. Atkins (U of S: University of Saskatchewan)H-Index: 9
#2BiousseH-Index: 1
Last. Nancy J. NewmanH-Index: 72
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: Optic neuritis is a common cause of visual loss in young patients, typically presenting with painful monocular visual loss and decreased color vision. Visual function generally spontaneously improves over weeks, and 95% of patients return to visual acuity of at least 20/40 within 12 months. The initial magnetic resonance imaging (MRI) helps stratify the risk of multiple sclerosis (MS) in patients with acute isolated optic neuritis. In the Optic Neuritis Treatment Trial, the 10-year risk of MS ...
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Microglia are the resident immune cells of the central nervous system (CNS), including the retina. Similar to brain microglia, retinal microglia are responsible for retinal surveillance, rapidly responding to changes in the environment by altering morphotype and function. Microglia become activated in inflammatory responses in neurodegenerative diseases, including multiple sclerosis (MS). When activated by stress stimuli, retinal microglia change their morphology and activity, with either benefi...
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#1Clara Grazia Chisari (University of Catania)H-Index: 9
#2Mario Damiano Toro (University of Catania)H-Index: 12
Last. Francesco PattiH-Index: 59
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Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS). Aiming to evaluate the retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT), patients with relapsing-remitting (RR) MS experiencing ON were consecutively enrolled. RNFL, ganglion cell layer (GCL), foveal thickness, and macular volume were evaluated in both the ON and unaffected (nON) eye within six days from the relapse onset (T0) and after six months (T1). Ninety patients were enrolled. At T0, ON eyes ...
4 CitationsSource