CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer
Abstract
Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol (E2) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome wide-significant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8×10(-11)). SNP rs727479 was also among those most strongly associated with...
Paper Details
Title
CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer
Published Date
Nov 16, 2015
Journal
Volume
23
Issue
2
Pages
77 - 91
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