PDL1 Regulation by p53 via miR-34
Volume: 108, Issue: 1
Published: Nov 17, 2015
Abstract
Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non-small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that PDL1 is regulated by p53 via miR-34.p53 wild-type and p53-deficient cell lines (p53(-/-) and p53(+/+) HCT116, p53-inducible H1299, and p53-knockdown H460) were used to determine if p53 regulates PDL1 via miR-34. PDL1 and miR-34a expression were analyzed in...
Paper Details
Title
PDL1 Regulation by p53 via miR-34
Published Date
Nov 17, 2015
Volume
108
Issue
1
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