Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts
Abstract
Achieving effective treatment outcomes for patients with glioblastoma (GBM) has been impeded by many obstacles, including the pharmacokinetic limitations of antitumor agents, such as topotecan (TPT). Here, we demonstrate that intravenous administration of a novel nanoliposomal formulation of TPT (nLS-TPT) extends the survival of mice with intracranial GBM xenografts, relative to administration of free TPT, because of improved biodistribution and...
Paper Details
Title
Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts
Published Date
Sep 27, 2011
Journal
Volume
13
Issue
12
Pages
1288 - 1295
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History