Published on Jan 1, 2013in Human Brain Mapping4.421
· DOI :10.1002/HBM.21412
Heidi I.L. Jacobs30
Estimated H-index: 30
(UM: Maastricht University),
Elizabeth C. Leritz19
Estimated H-index: 19
(Harvard University)
+ 7 AuthorsDavid H. Salat77
Estimated H-index: 77
(Harvard University)
Cerebral white matter damage is not only a commonly reported consequence of healthy aging, but is also associated with cognitive decline and dementia. The aetiology of this damage is unclear; however, individuals with hypertension have a greater burden of white matter signal abnor- malities (WMSA) on MR imaging than those without hypertension. It is therefore possible that elevated blood pressure (BP) impacts white matter tissue structure which in turn has a negative impact on cognition. However, little information exists about whether vascular health indexed by BP mediates the relationship between cognition and white matter tissue structure. We used diffusion tensor imag- ing to examine the impact of vascular health on regional associations between white matter integrity and cognition in healthy older adults spanning the normotensive to moderate-severe hypertensive BP range (43-87 years; N ¼ 128). We examined how white matter structure was associated with perform- ance on tests of two cognitive domains, executive functioning (EF) and processing speed (PS), and how patterns of regional associations were modified by BP and WMSA. Multiple linear regression and structural equation models demonstrated associations between tissue structure, EF and PS in frontal, temporal, parietal, and occipital white matter regions. Radial diffusivity was more prominently associ- ated with performance than axial diffusivity. BP only minimally influenced the relationship between
📖 Papers frequently viewed together
62.6k Citations
11 Authors (Stephen M. Smith, ..., Behrens Tej.)
5,289 Citations
290 Citations
#1Harry T. ReisH-Index: 80
#2Charles M. JuddH-Index: 48
Introduction to the second edition Harry T. Reis and Charles M. Judd 1. Scratch an itch with a brick: why we do research Susan T. Fiske Part I. Design and Inference Considerations: 2. Research design and issues of validity Marilynn B. Brewer and William D. Crano 3. Research design Eliot R. Smith 4. Causal inference and generalization in field settings: experimental and quasi-experimental designs Stephen G. West, Heining Cham and Yu Liu 5. Field research methods Elizabeth Levy Paluck and Robert B...
1,454 CitationsSource
#1Mark van der WelH-Index: 7
#2Iris E. BuunkH-Index: 1
Last. J. Carel BakxH-Index: 9
view all 5 authors...
PURPOSE Current offi ce blood pressure measurement (OBPM) is often not exe- cuted according to guidelines and cannot prevent the white-coat effect. Serial, automated, oscillometric OBPM has the potential to overcome both these prob- lems. We therefore developed a 30-minute OBPM method that we compared with daytime ambulatory blood pressure. METHODS Patients referred to a primary care diagnostic center for 24-hour ambulatory blood pressure monitoring (ABPM) had their blood pressure mea- sured usi...
42 CitationsSource
#1Elizabeth C. Leritz (VA Boston Healthcare System)H-Index: 19
#2David H. Salat (Harvard University)H-Index: 77
Last. William P. Milberg (Harvard University)H-Index: 65
view all 9 authors...
Abstract We examined how wide ranges in levels of risk factors for cerebrovascular disease are associated with thickness of the human cerebral cortex in 115 individuals ages 43–83 with no cerebrovascular or neurologic history. Cerebrovascular risk factors included blood pressure, cholesterol, body mass index, creatinine, and diabetes-related factors. Variables were submitted into a principal components analysis that confirmed four orthogonal factors (blood pressure, cholesterol, cholesterol/meta...
94 CitationsSource
#1Allison Brown (U of C: University of Calgary)H-Index: 10
#2Carly A. McMorris (U of C: University of Calgary)H-Index: 10
Last. Marc J. PoulinH-Index: 41
view all 7 authors...
Abstract The mechanisms by which aerobic fitness confers beneficial effects on cognition with aging are unclear but may involve cerebrovascular adaptations. In a cross-sectional study of women from the community (n = 42; age range = 50–90 years), we sought to determine whether physical fitness is associated with higher cerebrovascular function, and its relationship to cognition. Main outcome measures included resting cerebral blood flow, cerebrovascular reserve, physical fitness (i.e., V ˙ O 2 m...
139 CitationsSource
#1Yu Zhang (SFVAMC: San Francisco VA Medical Center)H-Index: 23
#2Antao Du (SFVAMC: San Francisco VA Medical Center)H-Index: 24
Last. Norbert Schuff (UCSF: University of California, San Francisco)H-Index: 95
view all 8 authors...
In diffusion tensor imaging (DTI), interpreting changes in terms of fractional anisotropy (FA) and mean diffusivity or axial (D||) and radial (D⊥) diffusivity can be ambiguous. The main objective of this study was to gain insight into the heterogeneity of age-related diffusion changes in human brain white matter by analyzing relationships between the diffusion measures in terms of concordance and discordance instead of evaluating them separately, which is difficult to interpret. Fifty-one cognit...
79 CitationsSource
#1Lars Penke (Edin.: University of Edinburgh)H-Index: 47
#2Ian J. Deary (Edin.: University of Edinburgh)H-Index: 184
Charlton et al. (2008) (Charlton, R.A., Landua, S., Schiavone, F., Barrick, T.R., Clark, C.A., Markus, H.S., Morris, R.G.A., 2008. Structural equation modelling investigation of age-related variance in executive function and DTI-measured white matter change. Neurobiol. Aging 29, 1547–1555) presented a model that suggests a specific age-related effect of white matter integrity on working memory. We illustrate potential pitfalls of structural equation modelling by criticizing their model for (a) i...
29 CitationsSource
#1Barbara Bucur (Duke University)H-Index: 12
#2David J. Madden (Duke University)H-Index: 65
Previous research has established that the effects of chronically increased blood pressure (BP) on cognition interact with adult age, but the relevant cognitive processes are not well defined. In this cross-sectional study, using a sample matched for age, years of education, and sex, 134 individuals with either normal BP (n = 71) or chronically high BP (n = 63) were categorized into younger (19–39 years), middle-aged (41–58 years), and older (60–79 years) groups. Using a between-subjects analysi...
52 CitationsSource
#1Edith V. Sullivan (Stanford University)H-Index: 111
#2Torsten Rohlfing (SRI: SRI International)H-Index: 59
Last. Adolf Pfefferbaum (Stanford University)H-Index: 124
view all 3 authors...
Abstract The integrity of white matter, as measured in vivo with diffusion tensor imaging (DTI), is disrupted in normal aging. A current consensus is that in adults advancing age affects anterior brain regions disproportionately more than posterior regions; however, the mainstay of studies supporting this anterior–posterior gradient is based primarily on measures of the corpus callosum. Using our quantitative fiber tracking approach, we assessed fiber tract integrity of samples of major white ma...
326 CitationsSource
#1Elizabeth C. Leritz (Brigham and Women's Hospital)H-Index: 19
#2David H. SalatH-Index: 77
Last. Regina E. McGlincheyH-Index: 33
view all 11 authors...
Elevated blood pressure (BP) is a significant risk factor for cerebrovascular disease (CVD), and it is becoming more prevalent as the population grows proportionally older and more sedentary. Complications arising from high BP are more widespread in African American communities relative to other racial groups (Howard et al., 2006; Taylor et al., 2008), and there is evidence to suggest that as a group, African Americans are more susceptible to the serious consequences of CVD, such as stroke and v...
64 CitationsSource
#1Saartje Burgmans (UM: Maastricht University)H-Index: 16
#2M.P.J. van Boxtel (UM: Maastricht University)H-Index: 35
Last. Naftali Raz (WSU: Wayne State University)H-Index: 78
view all 8 authors...
Abstract We investigated differences associated with age and hypertension, a common risk factor for vascular disease, in three aspects of white matter integrity — gross regional volumes of the white matter, volume of the white matter hyperintensities (WMH) and diffusion properties. We acquired MRI scans on 93 adult volunteers (age 50–77 years; 36 with diagnosis of hypertension or elevated blood pressure), and obtained all measures in seven brain regions: frontal, temporal, parietal and occipital...
101 CitationsSource
Cited By103
#1Rodrigo Ferretjans (UFMG: Universidade Federal de Minas Gerais)H-Index: 5
#2Renan P. Souza (UFMG: Universidade Federal de Minas Gerais)H-Index: 22
Last. Clarissa S. Gama (Deakin University)
view all 0 authors...
Objective: To test the hypothesis that genetic variations of cannabinoid receptors contribute to the pathophysiology of cognitive deficits in schizophrenia. Methods: In this genetic association case-control study, cannabinoid receptor polymorphisms CNR1 rs12720071 and CNR2 rs2229579 were tested for association with neurocognitive performance in 69 patients with schizophrenia and 45 healthy controls. Neurocognition was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS). Results...
#1Natalia S. Rost (Harvard University)H-Index: 56
#2James F. Meschia (Mayo Clinic)H-Index: 75
view all 7 authors...
Stroke is a leading cause of the adult disability epidemic in the United States, with a major contribution from poststroke cognitive impairment and dementia (PSCID), the rates of which are disproportionally high among the health disparity populations. Despite the PSCID's overwhelming impact on public health, a knowledge gap exists with regard to the complex interaction between the acute stroke event and highly prevalent preexisting brain pathology related to cerebrovascular and Alzheimer disease...
#1David A. HoageyH-Index: 6
Last. Kristen M. KennedyH-Index: 39
view all 4 authors...
Even within healthy aging, vascular risk factors can detrimentally influence cognition, with executive functions (EF) particularly vulnerable. Fronto-parietal white matter (WM) connectivity in part, supports EF and may be particularly sensitive to vascular risk. Here, we utilized structural equation modeling in 184 healthy adults (aged 20-94 years of age) to test the hypotheses that: 1) fronto-parietal WM microstructure mediates age effects on EF; 2) higher blood pressure (BP) and white matter h...
Introduction: Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Despite the extensive research, its pathophysiology remains largely unelucidated. Currently, more attention is being given to the disease’s vascular and inflammatory aspects. In this context, the renin-angiotensin system (RAS) emerges as a credible player in AD pathogenesis. RAS has multiple physiological functions, conducted by its two opposing axes: the classical, led by Angiotensin II (Ang II), and the alternat...
#1Benjamin Zimmerman (UIUC: University of Illinois at Urbana–Champaign)H-Index: 11
#2Bart Rypma (UTD: University of Texas at Dallas)H-Index: 36
Last. Monica Fabiani (UIUC: University of Illinois at Urbana–Champaign)H-Index: 69
view all 4 authors...
The process of aging includes changes in cellular biology that affect local interactions between cells and their environments and eventually propagate to systemic levels. In the brain, where neurons critically depend on an efficient and dynamic supply of oxygen and glucose, age-related changes in the complex interaction between the brain parenchyma and the cerebrovasculature have effects on health and functioning that negatively impact cognition and play a role in pathology. Thus, cerebrovascula...
#1Heidi I.L. Jacobs (UM: Maastricht University)H-Index: 30
#2Joost M. Riphagen (UM: Maastricht University)H-Index: 5
Last. Frans R.J. Verhey (UM: Maastricht University)H-Index: 102
view all 4 authors...
The locus coeruleus (LC) supplies norepinephrine to the brain, is one of the first sites of tau deposition in Alzheimer’s disease (AD) and modulates a variety of behaviors and cognitive functions. Transgenic mouse models showed that norepinephrine dysregulation after LC lesions exacerbates inflammatory responses, blood–brain barrier leakage (BBB), and cognitive deficits. Here, we investigated relationships between central norepinephrine metabolism, tau and beta-amyloid (Aβ), inflammation, BBB-dy...
12 CitationsSource
#1Emma Richards (Swansea University)H-Index: 4
#2Ian M. Thornton (University of Malta)H-Index: 26
Last. Andrea Tales (Swansea University)H-Index: 23
view all 4 authors...
Abstract We used the MILO (Multi-Item Localization) task to characterise the performance of a group of older adults diagnosed with mild to moderate vascular cognitive impairment (VCI). The MILO task is designed to explore the temporal context of visual search and in addition to measuring overall completion time, provides a profile of serial reaction time (SRT) patterns across all items in a sequence. Of particular interest here is the Vanish/Remain MILO manipulation that can identify problems wi...
#1Yaqiong Chai (SC: University of Southern California)H-Index: 5
#2Chaoran Ji (SC: University of Southern California)H-Index: 1
Last. Natasha LeporeH-Index: 24
view all 11 authors...
Introduction Sickle cell disease (SCD) is a hereditary blood disorder in which the oxygen-carrying hemoglobin molecule in red blood cells is abnormal. SCD patients are at increased risks for strokes and neurocognitive deficit, even though neurovascular screening and treatments have lowered the rate of overt strokes. Tract-specific analysis (TSA) is a statistical method to evaluate microstructural WM damage in neurodegenerative disorders, using diffusion tensor imaging (DTI). Methods We utilized ...
1 CitationsSource
Background Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) could provide treatment alternatives to stimulant medication for attention-deficit/hyperactivity disorder (ADHD), given some evidence for improvements in cognition and clinical symptoms. However, despite a lack of solid evidence for their use, rTMS and tDCS are already offered clinically and commercially in ADHD. This systematic review and meta-analysis aimed to critically appraise rT...
5 CitationsSource
#1Mia PihlajaH-Index: 1
#2Laura Failla (UH: University of Helsinki)H-Index: 1
Last. Kaisa M. HartikainenH-Index: 19
view all 4 authors...
We have previously shown invasive vagus nerve stimulation to improve attention and working memory and alter emotion-attention interaction in patients with refractory epilepsy, suggesting that VNS might be useful in the treatment of cognitive impairment. The current research focuses on whether non-invasive, transcutaneous vagus nerve stimulation (tVNS) has similar effects to VNS. Furthermore, we aimed to assess whether tVNS has an impact on cognitive control in general or on underlying brain phys...
1 CitationsSource