Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate
Abstract
An antibody-drug conjugate consisting of monomethyl auristatin E (MMAE) conjugated to the anti-CD30 monoclonal antibody (mAb) cAC10, with eight drug moieties per mAb, was previously shown to have potent cytotoxic activity against CD30(+) malignant cells. To determine the effect of drug loading on antibody-drug conjugate therapeutic potential, we assessed cAC10 antibody-drug conjugates containing different drug-mAb ratios in vitro and in...
Paper Details
Title
Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate
Published Date
Oct 15, 2004
Journal
Volume
10
Issue
20
Pages
7063 - 7070
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