Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
Abstract
Growing evidence suggests water-soluble, non-fibrillar forms of amyloid-β protein (Aβ) have important roles in Alzheimer's disease with toxicities mimicked by synthetic Aβ(1-42). However, no defined toxic structures acting via specific receptors have been identified and roles of proposed receptors, such as prion protein (PrP), remain controversial. Here we quantify binding to PrP of Aβ(1-42) after different durations of aggregation. We show...
Paper Details
Title
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
Published Date
Sep 11, 2013
Journal
Volume
4
Issue
2416
Pages
2416 - 2416
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