Discriminant nonnegative matrix factorization for classification of rectal bleeding in prostate cancer radiotherapy

External beam radiotherapy is one of the standard treatments for prostate cancer. Despite advanced radiotherapy techniques allowing precise dose delivery on cancer targets, efficiency of the treatment is limited by the risk of side-effects due to the irradiation to the surrounding organs. Characterizing the local dose–toxicity relationship is crucial to provide new recommendations for treatment planning. Standing on a voxel wise analysis, in...