Protein stickiness, rather than number of functional protein-protein interactions, predicts expression noise and plasticity in yeast

A hub protein is one that interacts with many functional partners. The annotation of hub proteins, or more generally the protein-protein interaction "degree" of each gene, requires quality genome-wide data. Data obtained using yeast two-hybrid methods contain many false positive interactions between proteins that rarely encounter each other in living cells, and such data have fallen out of favor.We find that protein "stickiness", measured as...