Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

Volume: 122, Issue: 7, Pages: 2454 - 2468
Published: Jul 2, 2012
Abstract
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed. Disruption of the blood-brain barrier (BBB) is an early feature of lesion formation that correlates with clinical exacerbation, leading to edema, excitotoxicity, and entry of serum proteins and inflammatory cells. Here, we identify astrocytic expression of VEGF-A as a key driver of BBB...
Paper Details
Title
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
Published Date
Jul 2, 2012
Volume
122
Issue
7
Pages
2454 - 2468
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