Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

Volume: 107, Issue: 13, Pages: 6058 - 6063
Published: Mar 30, 2010
Abstract
Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on Alzheimer's disease pathology, we evaluated NE effects on microglial key functions. NE stimulation of mouse microglia suppressed Aβ-induced cytokine and chemokine production and increased microglial migration and phagocytosis of Aβ. Induced degeneration of the locus ceruleus...
Paper Details
Title
Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine
Published Date
Mar 30, 2010
Volume
107
Issue
13
Pages
6058 - 6063
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