Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia.

Published on Dec 1, 2007in American Journal of Respiratory and Critical Care Medicine17.452
· DOI :10.1164/RCCM.200705-761OC
Leonardo Lorente37
Estimated H-index: 37
(Hospital Universitario de Canarias),
María Lecuona14
Estimated H-index: 14
+ 2 AuthorsAntonio Sierra17
Estimated H-index: 17
Rationale: Subglottic secretion drainage (SSD) appears to be effective in preventing ventilator-associated pneumonia (VAP), primarily by reducing early-onset pneumonia; but it may not prevent late-onset pneumonia. We tested the hypothesis using an endotracheal tube incorporating an ultrathin polyurethane cuff (which reduces channel formation and fluid leakage from the subglottic area), in addition to an SSD lumen, which would reduce the incidence of late-onset VAP.Objectives: To compare the incidence of VAP, using an endotracheal tube with polyurethane cuff and subglottic secretion drainage (ETT-PUC-SSD) versus a conventional endotracheal tube (ETT-C) with polyvinyl cuff, without subglottic secretion drainage.Methods: Clinical randomized trial in a 24-bed medical–surgical intensive care unit. Patients expected to require mechanical ventilation for more than 24 hours were randomly assigned to one of two groups: one was ventilated with ETT-PUC-SSD and the other with ETT-C.Measurements and Main Results: Trac...
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