TR3 Modulates Platinum Resistance in Ovarian Cancer
Abstract
In metastatic ovarian cancer, resistance to platinum chemotherapy is common. Although the orphan nuclear receptor TR3 (nur77/NR4A1) is implicated in mediating chemotherapy-induced apoptosis in cancer cells, its role in ovarian cancer has not been determined. In an ovarian cancer tissue microarray, TR3 protein expression was elevated in stage I tumors, but downregulated in a significant subset of metastatic tumors. Moreover, TR3 expression was...
Paper Details
Title
TR3 Modulates Platinum Resistance in Ovarian Cancer
Published Date
Jul 31, 2013
Journal
Volume
73
Issue
15
Pages
4758 - 4769
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