Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus
Abstract
Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71%) possessed a mutation(s) in rpoB encoding the β-subunit of RNA polymerase. Furthermore, 95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of an rpoB mutation in VISA phenotype...
Paper Details
Title
Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus
Published Date
Jul 1, 2011
Volume
49
Issue
7
Pages
2680 - 2684
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