Metastatic Breast Cancer Presenting as a Subconjunctival Mass

Published on Mar 1, 2014in Journal of Breast Cancer2.241
· DOI :10.4048/JBC.2014.17.1.88
Young Min Park12
Estimated H-index: 12
(PNU: Pusan National University),
Jong Ho Park1
Estimated H-index: 1
(PNU: Pusan National University)
+ 1 AuthorsJong Soo Lee17
Estimated H-index: 17
(PNU: Pusan National University)
Sources
Abstract
Breast cancer is the most common primary source of orbital metastasis. Metastasis occurs through hematogenous spread and predominantly involves the choroid. We present a case of a metastatic subconjunctival mass associated with primary breast cancer. To our knowledge, this is the first reported case of its kind. A 41-year-old woman presented with complaints of conjunctival injection and a foreign body sensation in the left eye. She had a history of breast cancer and had been treated 2 years previously with modified radical mastectomy followed by adjuvant radiotherapy and chemotherapy. Slit-lamp examination showed a cystic mass under the temporal bulbar conjunctiva, associated with dilated overlying conjunctival vessels. An excisional biopsy revealed a poorly differentiated adenocarcinoma. Positron emission tomography examination for systemic malignancy revealed multiple systemic metastasis. Metastatic disease should be considered in the differential diagnosis of subconjunctival lesions, and ophthalmic manifestations can play an important role in the detection of metastatic spread of a known primary breast cancer.
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15 CitationsSource
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53 CitationsSource
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Summary Background The management of brain metastases is a significant health care problem. An estimated 20–40% of cancer patients will develop metastatic cancer to the brain during the course of their illness. Methods A systematic review of randomized trials on adult cancer patients with single or multiple brain metastases from cancer of any histology was conducted. Eligible studies investigated external beam radiotherapy or radiosurgery in one of the study arms. Outcomes of interest included s...
171 CitationsSource
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Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma
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Periorbital cellulitis is a condition frequently referred to general physicians rather than ophthalmologists. It can be caused by malignant disease.
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In a retrospective study the records of 34 consecutive cases with tumors metastatic to the orbit were reviewed with special attention to the management and prognosis of these patients. The primary tumor site was the breast in 20 patients, prostate in 5, kidney in 2 and skin in 2. The remaining 5 patients had other primary tumour sites. The symptoms of orbital metastasis preceded the detection of the primary tumor in 8 cases (24%). Twenty patients died after a mean interval of 25 months following...
50 CitationsSource
• A review of the charts of 112 patients (141 eyes) presenting with a metastasis to the eye or orbit revealed that breast cancer was the most common primary tumor (49.1%). The median survival time (MST) following choroidal metastasis for all stages of breast cancer was 314 days. The MST after choroidal metastasis in patients thought to have stage I or II breast cancer, prior to diagnosis of the metastasis, was longer than that of patients with stage III or IV cancer (873 vs 139 days, respectivel...
176 CitationsSource
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#1Inês Coutinho (UC: University of Coimbra)H-Index: 9
#2Marco Marques (UC: University of Coimbra)H-Index: 6
Last. Fernanda Águas (UC: University of Coimbra)H-Index: 3
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: Orbital metastasis is a rare event, and metastatic disease affecting the extraocular muscles is an even less frequent complication of solid tumors. Herein, we report an unusual case of ptosis as the initial presentation of an invasive breast cancer. A 68-year-old woman presented with III and VI partial nerve paresis, secondary to a compressive retrobulbar mass. Magnetic resonance imaging revealed an infiltrative lesion involving the extraocular muscles. Tissue biopsy yielded a result compatibl...
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