Metastatic Breast Cancer Presenting as a Subconjunctival Mass

Published on Mar 1, 2014in Journal of Breast Cancer2.241
· DOI :10.4048/JBC.2014.17.1.88
Young Min Park12
Estimated H-index: 12
(PNU: Pusan National University),
Jong Ho Park1
Estimated H-index: 1
(PNU: Pusan National University)
+ 1 AuthorsJong Soo Lee17
Estimated H-index: 17
(PNU: Pusan National University)
Breast cancer is the most common primary source of orbital metastasis. Metastasis occurs through hematogenous spread and predominantly involves the choroid. We present a case of a metastatic subconjunctival mass associated with primary breast cancer. To our knowledge, this is the first reported case of its kind. A 41-year-old woman presented with complaints of conjunctival injection and a foreign body sensation in the left eye. She had a history of breast cancer and had been treated 2 years previously with modified radical mastectomy followed by adjuvant radiotherapy and chemotherapy. Slit-lamp examination showed a cystic mass under the temporal bulbar conjunctiva, associated with dilated overlying conjunctival vessels. An excisional biopsy revealed a poorly differentiated adenocarcinoma. Positron emission tomography examination for systemic malignancy revealed multiple systemic metastasis. Metastatic disease should be considered in the differential diagnosis of subconjunctival lesions, and ophthalmic manifestations can play an important role in the detection of metastatic spread of a known primary breast cancer.
#1Eunyoung Kang (Seoul National University Bundang Hospital)H-Index: 26
#2Sung-Won Kim (Seoul National University Bundang Hospital)H-Index: 39
Last. Sung Won Kim (Seoul National University Bundang Hospital)H-Index: 32
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Most studies related to BRCA mutations have been performed in Western populations, and only a few small studies have been conducted in Korean populations. In 2007, the Korean Hereditary Breast Cancer (KOHBRA) Study was established to obtain evidence for the accurate risk assessment and management of hereditary breast and ovarian cancer (HBOC) in Korea. Between May 2007 and May 2010, the first phase of the KOHBRA Study was performed to estimate the prevalence of BRCA1/2 mutations among patients a...
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. Context: Breast cancer is the most common malignancy in women, with increasing incidence in Europe and North America. The frequency of involvement of the eye and visual pathways is reported to be as high as 30% in patients with known metastatic disease. In some cases, ophthalmic involvement can be the first sign of metastatic spread. Metastasis occurs via the haematogenous route and predominantly involves the choroid. Metastases to other ocular structures, the orbit and the visual pathways hav...
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171 CitationsSource
#1Zee-Wan WongH-Index: 2
#2Steven J. Phillips (Duke University)H-Index: 1
Last. Matthew J. Ellis (Duke University)H-Index: 97
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#1Linda Mewis (University of Texas Health Science Center at Houston)H-Index: 2
#2Sue E. Young (University of Texas Health Science Center at Houston)H-Index: 1
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#1Inês Coutinho (UC: University of Coimbra)H-Index: 9
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