HPLC analysis of the antifungal agent posaconazole in patients with haematological diseases

Summary Posaconazole is a new antifungal drug used in prophylaxis and therapy of fungal infections in patients with immunodeficiency. In the clinical development, posaconazole exhibits variable oral bioavailability. Hence drug monitoring is recommended. For this purpose, a rapid and a convenient high‐performance liquid chromatography (HPLC) method has been developed. To 200 μ l serum, 50 μ l internal standard (itraconazole) was added. After...