Dynamic glucose enhanced (DGE) MRI for combined imaging of blood–brain barrier break down and increased blood volume in brain cancer

Published on Dec 1, 2015in Magnetic Resonance in Medicine3.635
· DOI :10.1002/MRM.25995
Xiang Xu15
Estimated H-index: 15
(ICSCI: Kennedy Krieger Institute),
Kannie W.Y. Chan23
Estimated H-index: 23
(ICSCI: Kennedy Krieger Institute)
+ 8 AuthorsPeter C.M. van Zijl109
Estimated H-index: 109
(ICSCI: Kennedy Krieger Institute)
Sources
Abstract
Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using d-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown.
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Uptake of administered D-glucose (Glc) or 2-deoxy-D-glucose (2DG) has been indirectly mapped through the chemical exchange (CE) between glucose hydroxyl and water protons using CE-dependent saturation transfer (glucoCEST) magnetic resonance imaging (MRI). We propose an alternative technique—on-resonance CE-sensitive spin-lock (CESL) MRI—to enhance responses to glucose changes. Phantom data and simulations suggest higher sensitivity for this ‘glucoCESL’ technique (versus glucoCEST) in the interme...
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Dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) has shown potential for tumor imaging using D-glucose as a biodegradable contrast agent. The DGE signal change is small at 3 T (around 1%) and accurate detection is hampered by motion. The intravenous D-glucose injection is associated with transient side effects that can indirectly generate subject movements. In this study, the aim was to study DGE arterial input functions (AIFs) in healthy volunteers at 3 T for different scanning p...
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